|
humans
generate new genes claim
“Abstract
“Most new genes arise from existing genes through
duplication or recombination. The origin of new genes
from noncoding DNA is extremely rare, and very few eukaryotic
examples are known. We present evidence for the de novo
origin of at least three human protein-coding genes
since the divergence with chimp. Each of these genes
has no protein-coding homologs in any other genome,
but is supported by evidence from expression and, importantly,
proteomics data. The absence of these genes in chimp
and macaque cannot be explained by sequencing gaps or
annotation error. High-quality sequence data indicate
that these loci are noncoding DNA in other primates.
Furthermore, chimp, gorilla, gibbon, and macaque share
the same disabling sequence difference, supporting the
inference that the ancestral sequence was noncoding
over the alternative possibility of parallel gene inactivation
in multiple primate lineages. The genes are not well
characterized, but interestingly, one of them was first
identified as an up-regulated gene in chronic lymphocytic
leukemia. This is the first evidence for entirely novel
human-specific protein-coding genes originating from
ancestrally noncoding sequences.”
Full .pdf paper, paywall-protected, is
available from this page for $15.00:
Recent de novo origin of human protein-coding genes
by David G. Knowles and Aoife McLysaght, Genome Research,
2 September, 2009
the web address for the article above is
https://www.abelard.org/news/lite062009.php#gene_generation_050909
|
advertising
disclaimer
|
